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Some clinical studies and recent reviews suggest that oral glutathione may contribute to brightening or melasma-related improvement in certain contexts, often around the 250 to 500 mg per day range, but the body of evidence is still relatively small and not as robust as the marketing often implies

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They confirmed that GT can down-regulate the activation of microglia and astrocyte, lower proinflammatory cytokine/enzyme expression, and boost the nuclear factor erythroid2-related factor 2 (Nrf2)-antioxidant response levels